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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: 50S ribosomal protein L2

UniprotKB/SwissProt ID: RL2_ECOLI (P60422)

Gene Name: rplB

Organism: Escherichia coli (strain K12).

Function: One of the primary rRNA binding proteins. Located near the base of the L1 stalk, it is probably also mobile. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is highly controversial. In the E.coli 70S ribosome in the initiation state it has been modeled to make several contacts with the 16S rRNA (forming bridge B7b, PubMed:12809609); these contacts are broken in the model with bound EF-G.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization:

PDB :
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Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR002171
IPR005880
IPR008991
IPR012340
IPR014722
3D Structure Databases:
3D structure databases
EntryMethodResolution (A)ChainPositionsView
1P85 EM 12.30 A A2-273Link
1P86 EM 11.50 A A2-273Link
1VS6 X-ray 3.46 A C1-273Link
1VS8 X-ray 3.46 A C1-273Link
1VT2 X-ray 3.30 A C1-273Link
2AW4 X-ray 3.46 A C1-273Link
2AWB X-ray 3.46 A C1-273Link
2GYA EM 15.00 A A39-264Link
2GYC EM 15.00 A A39-265Link
2I2T X-ray 3.22 A C2-272Link
2I2V X-ray 3.22 A C2-272Link
2J28 EM 8.00 A C4-270Link
2QAM X-ray 3.21 A C2-273Link
2QAO X-ray 3.21 A C2-273Link
2QBA X-ray 3.54 A C2-273Link
2QBC X-ray 3.54 A C2-273Link
2QBE X-ray 3.30 A C2-273Link
2QBG X-ray 3.30 A C2-273Link
2QBI X-ray 4.00 A C2-273Link
2QBK X-ray 4.00 A C2-273Link
2QOV X-ray 3.93 A C2-273Link
2QOX X-ray 3.93 A C2-273Link
2QOZ X-ray 3.50 A C2-273Link
2QP1 X-ray 3.50 A C2-273Link
2RDO EM 9.10 A C2-273Link
2VHM X-ray 3.74 A C1-273Link
2VHN X-ray 3.74 A C1-273Link
2WWQ EM 5.80 A C2-272Link
2Z4L X-ray 4.45 A C2-273Link
2Z4N X-ray 4.45 A C2-273Link
3BBX EM 10.00 A C1-273Link
3DF2 X-ray 3.50 A C1-273Link
3DF4 X-ray 3.50 A C1-273Link
3E1B EM - N1-270Link
3E1D EM - N1-270Link
3FIK EM 6.70 A C2-272Link
3I1N X-ray 3.19 A C1-273Link
3I1P X-ray 3.19 A C1-273Link
3I1R X-ray 3.81 A C1-273Link
3I1T X-ray 3.81 A C1-273Link
3I20 X-ray 3.71 A C1-273Link
3I22 X-ray 3.71 A C1-273Link
3IZT EM - D1-273Link
3IZU EM - D1-273Link
3J01 EM - 62-273Link
3J0T EM 12.10 A D2-272Link
3J0W EM 14.70 A D2-272Link
3J0Y EM 13.50 A D2-272Link
3J11 EM 13.10 A D2-272Link
3J12 EM 11.50 A D2-272Link
3J14 EM 11.50 A D2-272Link
3J19 EM 8.30 A C2-272Link
3J37 EM 9.80 A D2-273Link
3J4X EM 12.00 A C1-272Link
3J50 EM 20.00 A C1-272Link
3J51 EM 17.00 A C1-272Link
3J52 EM 12.00 A C1-272Link
3J54 EM 13.00 A C1-272Link
3J56 EM 15.00 A C1-272Link
3J58 EM 17.00 A C1-272Link
3J5A EM 12.00 A C1-272Link
3J5C EM 17.00 A C1-272Link
3J5E EM 17.00 A C1-272Link
3J5G EM 20.00 A C1-272Link
3J5I EM 15.00 A C1-272Link
3J5K EM 9.00 A C1-272Link
3J5O EM 6.80 A C1-273Link
3J5U EM 7.60 A D2-273Link
3J5W EM 7.60 A D2-273Link
3KCR EM - 61-273Link
3OAS X-ray 3.25 A C2-272Link
3OAT X-ray 3.25 A C2-272Link
3OFC X-ray 3.19 A C2-272Link
3OFD X-ray 3.19 A C2-272Link
3OFQ X-ray 3.10 A C2-272Link
3OFR X-ray 3.10 A C2-272Link
3OFZ X-ray 3.29 A C2-272Link
3OG0 X-ray 3.29 A C2-272Link
3ORB X-ray 3.30 A C1-273Link
3R8S X-ray 3.00 A C2-272Link
3R8T X-ray 3.00 A C2-272Link
3SGF X-ray 3.20 A C1-273Link
3UOS X-ray 3.70 A C1-273Link
487D EM 7.50 A I62-172Link
4GAR X-ray 3.30 A C1-273Link
4GAU X-ray 3.30 A C1-273Link
4KIX X-ray 2.90 A C1-273Link
4KIZ X-ray 2.90 A C1-273Link
4KJ1 X-ray 2.90 A C1-273Link
4KJ3 X-ray 2.90 A C1-273Link
4KJ5 X-ray 2.90 A C1-273Link
4KJ7 X-ray 2.90 A C1-273Link
4KJ9 X-ray 2.90 A C1-273Link
4KJB X-ray 2.90 A C1-273Link
The S-nitrosylation sites of RL2_ECOLI

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
16-----MAVVK C KPTSPGRRHV -----CCCEE E CCCCCCCCEE 4.28%EC0222178444-
26-----MAVVK C KPTSPGRRHV -----CCCEE E CCCCCCCCEE 4.28%EC0219483679in vitro
3188SGEMRKVEAD C RATLGEVGNA CCCEEEECCC C CEEEEEEECC 4.03%EC0222178444-
4188SGEMRKVEAD C RATLGEVGNA CCCEEEECCC C CEEEEEEECC 4.03%EC0219483679in vitro