logo
  Home | Contact us | Browse | Quick Search by UniProtKB ID, Keyword, PDBID

Menu:

Latest news:

Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

Read more...


Protein Name: Heterogeneous nuclear ribonucleoprotein A1

UniprotKB/SwissProt ID: ROA1_HUMAN (P09651)

Gene Name: HNRNPA1

Synonyms: HNRPA1

Organism: Homo sapiens (Human).

Function: Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and may modulate splice site selection. May play a role in HCV RNA replication.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Nucleus. Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Shuttles continuously between the nucleus and the cytoplasm along with mRNA. Component of ribonucleosomes. In the course of viral infection, colocalizes with H

PDB :
( If your security settings prevent Jmol from running, please register http://140.138.144.145/ as a safe location in your Java settings. )

Network with metabolic pathway:
Kegg map ID Pathway Link
map03040Spliceosome
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR000504
IPR012677

3D Structure Databases:
3D structure databases
EntryMethodResolution (A)ChainPositionsView
1HA1 X-ray 1.75 A A1-184Link
1L3K X-ray 1.10 A A1-196Link
1PGZ X-ray 2.60 A A2-195Link
1PO6 X-ray 2.10 A A8-189Link
1U1K X-ray 2.00 A A1-196Link
1U1L X-ray 2.00 A A1-196Link
1U1M X-ray 2.00 A A1-196Link
1U1N X-ray 2.10 A A1-196Link
1U1O X-ray 2.00 A A1-196Link
1U1P X-ray 1.90 A A1-196Link
1U1Q X-ray 1.80 A A1-196Link
1U1R X-ray 1.80 A A1-196Link
1UP1 X-ray 1.90 A A3-184Link
2H4M X-ray 3.05 A C/D309-357Link
2LYV NMR - A2-196Link
2UP1 X-ray 2.10 A A8-190Link

The S-nitrosylation sites of ROA1_HUMAN

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
143HFEQWGTLTD C VVMRDPNTKR HHHHCCCEEE E EEEECCCCCC 1.78%HC0822178444-
243HFEQWGTLTD C VVMRDPNTKR HHHHCCCEEE E EEEECCCCCC 1.78%HC0820140087in vivo