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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

UniprotKB/SwissProt ID: RPN1_HUMAN (P04843)

Gene Name: RPN1

Organism: Homo sapiens (Human).

Function: Essential subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Endoplasmic reticulum membrane; Single-pass type I membrane protein. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

Protein disease:
Disease database Database Entry Disease information
OMIM180470RIBOPHORIN I; RPN1
Network with metabolic pathway:
Kegg map ID Pathway Link
map00510N-Glycan biosynthesis
map04141Protein processing in endoplasmic reticulum
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information

The S-nitrosylation sites of RPN1_HUMAN

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
1477PAAEARMKVA C ITEQVLTLVN   4.41%HC0425040305in vivo
2477PAAEARMKVA C ITEQVLTLVN   4.41%HC0419483679in vivo
3477PAAEARMKVA C ITEQVLTLVN   4.41%HC0420140087in vivo