Protein Name: 40S ribosomal protein SA
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UniprotKB/SwissProt ID: RSSA_HUMAN (P08865)
Gene Name: RPSA
Synonyms: LAMBR, LAMR1
Organism: Homo sapiens (Human).
Function: Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA- precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Acts as a PPP1R16B-dependent substrate of PPP1CA. Also acts as a receptor for several other ligands, including the pathogenic prion protein, viruses, and bacteria.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell membrane. Cytoplasm. Nucleus (By similarity). Note=67LR is found at the surface of the plasma membrane, with its C-terminal laminin-binding domain accessible to extracellular ligands. 37LRP is found at the cell surface, in the cytoplasm and in the n
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PDB :
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Protein disease:
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| Disease database |
Database Entry |
Disease information | | OMIM | 150370 | LAMININ RECEPTOR 1; LAMR1 ;;LAMBR;; RIBOSOMAL PROTEIN SA; RPSA;; LAMININ RECEPTOR, 67-KD; 67 | | OMIM | 604400 | ARRHYTHMOGENIC RIGHT VENTRICULAR DYSPLASIA, FAMILIAL, 5; ARVD5 ;;ARRHYTHMOGENIC RIGHT VENTRI |
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Network with metabolic pathway:
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Graphical Visualization of S-nitrosylation Sites:
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| Overview of Protein S-nitrosylation Sites with Functional and Structural Information |  |
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