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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Bile acyl-CoA synthetase

UniprotKB/SwissProt ID: S27A5_MOUSE (Q4LDG0)

Gene Name: Slc27a5

Synonyms: Acsb, Acsvl6, Fatp5, Vlacsr

Organism: Mus musculus (Mouse).

Function: Acyl-CoA synthetase involved in bile acid metabolism. Proposed to catalyze the first step in the conjugation of C24 bile acids (choloneates) to glycine and taurine before excretion into bile canaliculi by activating them to their CoA thioesters. Seems to activate secondary bile acids entering the liver from the enterohepatic circulation (By similarity).

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity).

Network with metabolic pathway:
Kegg map ID Pathway Link
map00120Primary bile acid biosynthesis
map03320PPAR signaling pathway
map04976Bile secretion
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR000873