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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial

UniprotKB/SwissProt ID: SCOT1_MOUSE (Q9D0K2)

Gene Name: Oxct1

Synonyms: Oxct, Scot

Organism: Mus musculus (Mouse).

Function: Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate (By similarity).

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Mitochondrion matrix (By similarity).

Network with metabolic pathway:
Kegg map ID Pathway Link
map00072Synthesis and degradation of ketone bodies
map00280"Valine, leucine and isoleucine degradation"
map00650Butanoate metabolism
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information

The S-nitrosylation sites of SCOT1_MOUSE

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
167ATLLVGGFGL C GIPENLIGAL   4.80%MC1322865876in vivo
2235KSARNFNLPM C KAAGTTVVEV   2.27%MC0122865876in vivo
3456KGNAHKIMEK C TLPLTGKQCV   2.77%MC0521278135in vitro
4456KGNAHKIMEK C TLPLTGKQCV   2.77%MC0522865876in vivo
5504TVDDIKKSTG C DFAVSPNLMP   3.84%MC1021278135in vitro
6504TVDDIKKSTG C DFAVSPNLMP   3.84%MC1022865876in vivo