UniprotKB/SwissProt ID: SIN3A_HUMAN (Q96ST3)
Gene Name: SIN3A
Organism: Homo sapiens (Human).
Function: Acts as a transcriptional repressor. Corepressor for REST. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Also interacts with MXD1-MAX heterodimers to repress transcription by tethering SIN3A to DNA (By similarity). Acts cooperatively with OGT to repress transcription in parallel with histone deacetylation.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus. Nucleus, nucleolus. Note=Recruited to the nucleolus by SAP30L.
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