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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Alpha-1-syntrophin

UniprotKB/SwissProt ID: SNTA1_MOUSE (Q61234)

Gene Name: Snta1

Synonyms: Snt1

Organism: Mus musculus (Mouse).

Function: Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the extracellular matrix via the dystrophin glycoprotein complex. Plays an important role in synapse formation and in the organization of UTRN and acetylcholine receptors at the neuromuscular synapse. Binds to phosphatidylinositol 4,5- bisphosphate.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cell membrane, sarcolemma; Peripheral membrane protein; Cytoplasmic side. Cell junction. Cytoplasm, cytoskeleton. Note=In skeletal muscle, it localizes at the cytoplasmic side of the sarcolemmal membrane and at neuromuscular junctions.

PDB :
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Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR001478
IPR001849
IPR015482

3D Structure Databases:
3D structure databases
EntryMethodResolution (A)ChainPositionsView
1QAV X-ray 1.90 A A77-164Link
1Z86 NMR - A79-165Link
1Z87 NMR - A2-264Link
2ADZ NMR - A2-264Link
2PDZ NMR - A79-164Link
4HOP X-ray 2.29 A A/C/E77-162Link

The S-nitrosylation sites of SNTA1_MOUSE

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
1220SLKMAYVSRR C TPTDPEPRYL CCCHHHCCCC C CCCCCCCCCC 5.33%MC0921278135in vitro
2220SLKMAYVSRR C TPTDPEPRYL CCCHHHCCCC C CCCCCCCCCC 5.33%MC0922865876in vivo