UniprotKB/SwissProt ID: SOCS2_HUMAN (O14508)
Gene Name: SOCS2
Synonyms: CIS2, SSI2, STATI2
Organism: Homo sapiens (Human).
Function: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS2 appears to be a negative regulator in the growth hormone/IGF1 signaling pathway. Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin- protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization:
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PDB :
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