UniprotKB/SwissProt ID: SRC8_HUMAN (Q14247)
Gene Name: CTTN
Synonyms: EMS1
Organism: Homo sapiens (Human).
Function: Contributes to the organization of the actin cytoskeleton and cell structure. In complex with ABL1 and MYLK regulates cortical actin-based cytoskeletal rearrangement critical to sphingosine 1-phosphate (S1P)-mediated endothelial cell (EC) barrier enhancement. Plays a role in the regulation of cell migration. Plays a role in the invasiveness of cancer cells, and the formation of metastases.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm, cytoskeleton. Cell projection, lamellipodium. Cell projection, ruffle. Cell projection, dendrite (By similarity). Cell projection, dendritic spine (By similarity). Note=Associated with membrane ruffles and lamellipodia. In the presence of CTTN
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