Protein Name: Stromal interaction molecule 1
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UniprotKB/SwissProt ID: STIM1_HUMAN (Q13586)
Gene Name: STIM1
Synonyms: GOK
Organism: Homo sapiens (Human).
Function: Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Acts as Ca(2+) sensor in the endoplasmic reticulum via its EF-hand domain. Upon Ca(2+) depletion, translocates from the endoplasmic reticulum to the plasma membrane where it activates the Ca(2+) release-activated Ca(2+) (CRAC) channel subunit, TMEM142A/ORAI1.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Cytoplasm, cytoskeleton. Note=Translocates from the endoplasmic reticulum to the cell membrane in response to a depletion of intracel
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PDB :
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Protein disease:
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| Disease database |
Database Entry |
Disease information | | KEGG | H00093 | Combined immunodeficiencies (CIDs), including the following nine diseases: X-linked hyper IgM syndro | | OMIM | 160565 | MYOPATHY, TUBULAR AGGREGATE ;;TUBULAR AGGREGATE MYOPATHY | | OMIM | 605921 | STROMAL INTERACTION MOLECULE 1; STIM1 | | OMIM | 612783 | IMMUNE DYSFUNCTION WITH T-CELL INACTIVATION DUE TO CALCIUM ENTRY DEFECT 2 |
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Network with metabolic pathway:
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Graphical Visualization of S-nitrosylation Sites:
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| Overview of Protein S-nitrosylation Sites with Functional and Structural Information |  |
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