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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Synaptic vesicle glycoprotein 2A

UniprotKB/SwissProt ID: SV2A_MOUSE (Q9JIS5)

Gene Name: Sv2a

Synonyms: Kiaa0736, Sv2

Organism: Mus musculus (Mouse).

Function: Plays a role in the control of regulated secretion in neural and endocrine cells, enhancing selectively low-frequency neurotransmission. Positively regulates vesicle fusion by maintaining the readily releasable pool of secretory vesicles. Receptor for the botulinium neurotoxin type A/BOTA.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Multi-pass membrane protein (By similarity). Note=Enriched in chromaffin granules, not present in adrenal microsomes. Associated with both insulin granules and synaptic-like microvesicles

Network with metabolic pathway:
Kegg map ID Pathway Link
map04512ECM-receptor interaction
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR005829
IPR005988
IPR007114
IPR011701

The S-nitrosylation sites of SV2A_MOUSE

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
1198FVLPSAEKDM C LSDSNKGMLG HHHHHHHHHH C CCHHHHHHHH 4.76%MC0224895380-