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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: T-complex protein 1 subunit theta

UniprotKB/SwissProt ID: TCPQ_HUMAN (P50990)

Gene Name: CCT8

Synonyms: C21orf112, CCTQ, KIAA0002

Organism: Homo sapiens (Human).

Function: Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Known to play a role, in vitro, in the folding of actin and tubulin.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.

Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR001969
IPR002194
IPR002423
IPR008950
IPR012721

The S-nitrosylation sites of TCPQ_HUMAN

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
1148KAHEILPNLV C CSAKNLRDID HHHHHHHHHH H CCCCCCCCHH 1.38%HC0722178444-
2148KAHEILPNLV C CSAKNLRDID HHHHHHHHHH H CCCCCCCCHH 1.38%HC0719483679in vivo
3149AHEILPNLVC C SAKNLRDIDE HHHHHHHHHH C CCCCCCCHHH 3.27%HC0622178444-
4149AHEILPNLVC C SAKNLRDIDE HHHHHHHHHH C CCCCCCCHHH 3.27%HC0619483679in vivo
5430AKQITSYGET C PGLEQYAIKK HHHHHHHHHC C CHHHHHHHHH 1.88%HC0819483679in vivo