Protein Name: Tectonin beta-propeller repeat-containing protein 1
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UniprotKB/SwissProt ID: TCPR1_HUMAN (Q7Z6L1)
Gene Name: TECPR1
Synonyms: KIAA1358
Organism: Homo sapiens (Human).
Function: Tethering factor involved in autophagy. Involved in autophagosome maturation by promoting the autophagosome fusion with lysosomes: acts by associating with both the ATG5-ATG12 conjugate and phosphatidylinositol-3-phosphate (PtdIns(3)P) present at the surface of autophagosomes. Also involved in selective autophagy against bacterial pathogens, by being required for phagophore/preautophagosomal structure biogenesis and maturation.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasmic vesicle, autophagosome membrane. Lysosome membrane. Note=Localizes to Lysosome membranes, and binds PtdIns(3)P at the surface of autophagosome. Localizes to autolysosomes, a vesicle formed by the fusion between autophagosomes and lysosomes.
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Protein disease:
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| Disease database |
Database Entry |
Disease information | | OMIM | 614781 | TECTONIN BETA-PROPELLER REPEAT-CONTAINING 1; TECPR1 |
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Graphical Visualization of S-nitrosylation Sites:
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| Overview of Protein S-nitrosylation Sites with Functional and Structural Information |  |
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