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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Protein-glutamine gamma-glutamyltransferase 2

UniprotKB/SwissProt ID: TGM2_HUMAN (P21980)

Gene Name: TGM2

Organism: Homo sapiens (Human).

Function: Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization:

PDB :
( If your security settings prevent Jmol from running, please register http://140.138.144.145/ as a safe location in your Java settings. )

Network with metabolic pathway:
Kegg map ID Pathway Link
map05016Huntington's disease
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR001102
IPR002931
IPR008957
IPR008958
IPR013783
IPR013808
IPR014756
3D Structure Databases:
3D structure databases
EntryMethodResolution (A)ChainPositionsView
1FAU Model - A1-687Link
1KV3 X-ray 2.80 A A/B/C/D/E/F1-687Link
2Q3Z X-ray 2.00 A A1-687Link
3LY6 X-ray 3.14 A A/B/C1-687Link
3S3J X-ray 2.25 A A2-687Link
3S3P X-ray 2.50 A A2-687Link
3S3S X-ray 2.30 A A2-687Link
The S-nitrosylation sites of TGM2_HUMAN

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
110-MAEELVLER C DLELETNGRD -CCCCEEEEE E EEECCCCCHH 5.24%HC0222178444-
210-MAEELVLER C DLELETNGRD -CCCCEEEEE E EEECCCCCHH 5.24%HC0211305905in vitro
327NGRDHHTADL C REKLVVRRGQ CCHHHHHHHC C CCCEEEECCC 5.63%HC0622178444-
427NGRDHHTADL C REKLVVRRGQ CCHHHHHHHC C CCCEEEECCC 5.63%HC0611305905in vitro
598WTATVVDQQD C TLSLQLTTPA EEEEEEECCC C EEEEEEECCC 3.42%HC1222178444-
698WTATVVDQQD C TLSLQLTTPA EEEEEEECCC C EEEEEEECCC 3.42%HC1211305905in vitro
7143GHFILLFNAW C PADAVYLDSE CEEEEEECCC C CHHCEECCCH 1.53%HC0722178444-
8143GHFILLFNAW C PADAVYLDSE CEEEEEECCC C CHHCEECCCH 1.53%HC0711305905in vitro
9230VGRVVSGMVN C NDDQGVLLGR EEEEHHHHHH C CCCCEEEECC 3.93%HC0722178444-
10230VGRVVSGMVN C NDDQGVLLGR EEEEHHHHHH C CCCCEEEECC 3.93%HC0711305905in vitro
11269DILRRWKNHG C QRVKYGQCWV HHHHHHHHCC C CEEEEEHHHH 1.49%HC0122178444-
12269DILRRWKNHG C QRVKYGQCWV HHHHHHHHCC C CEEEEEHHHH 1.49%HC0111305905in vitro
13277HGCQRVKYGQ C WVFAAVACTV CCCCEEEEEH H HHHHHHHHHH 2.65%HC1222178444-
14277HGCQRVKYGQ C WVFAAVACTV CCCCEEEEEH H HHHHHHHHHH 2.65%HC1211305905in vitro
15285GQCWVFAAVA C TVLRCLGIPT EHHHHHHHHH H HHHHHCCCCC 1.86%HC1222178444-
16285GQCWVFAAVA C TVLRCLGIPT EHHHHHHHHH H HHHHHCCCCC 1.86%HC1211305905in vitro
17336DKSEMIWNFH C WVESWMTRPD CCCCCEEEEE E EEEEEEECCC 3.68%HC0222178444-
18336DKSEMIWNFH C WVESWMTRPD CCCCCEEEEE E EEEEEEECCC 3.68%HC0211305905in vitro
19370TPQEKSEGTY C CGPVPVRAIK CCCCCCCEEE E ECCCEEEEEE 1.86%HC1022178444-
20370TPQEKSEGTY C CGPVPVRAIK CCCCCCCEEE E ECCCEEEEEE 1.86%HC102212679in vitro
21370TPQEKSEGTY C CGPVPVRAIK CCCCCCCEEE E ECCCEEEEEE 1.86%HC1022126794in vivo
22370TPQEKSEGTY C CGPVPVRAIK CCCCCCCEEE E ECCCEEEEEE 1.86%HC1011305905in vitro
23371PQEKSEGTYC C GPVPVRAIKE CCCCCCEEEE E CCCEEEEEEE 4.93%HC0122178444-
24371PQEKSEGTYC C GPVPVRAIKE CCCCCCEEEE E CCCEEEEEEE 4.93%HC012212679in vitro
25371PQEKSEGTYC C GPVPVRAIKE CCCCCCEEEE E CCCEEEEEEE 4.93%HC0122126794in vivo
26371PQEKSEGTYC C GPVPVRAIKE CCCCCCEEEE E CCCEEEEEEE 4.93%HC0111305905in vitro
27524VSYNGILGPE C GTKYLLNLNL EEECCEECCC E EEEEEEEEEE 10.64%HC0622178444-
28524VSYNGILGPE C GTKYLLNLNL EEECCEECCC E EEEEEEEEEE 10.64%HC062212679in vitro
29524VSYNGILGPE C GTKYLLNLNL EEECCEECCC E EEEEEEEEEE 10.64%HC0622126794in vivo
30524VSYNGILGPE C GTKYLLNLNL EEECCEECCC E EEEEEEEEEE 10.64%HC0611305905in vitro
31545EPFSEKSVPL C ILYEKYRDCL CCCCEEEEEE E ECHHHHCCCC 1.32%HC0722178444-
32545EPFSEKSVPL C ILYEKYRDCL CCCCEEEEEE E ECHHHHCCCC 1.32%HC0711305905in vitro
33554LCILYEKYRD C LTESNLIKVR EEECHHHHCC C CCCCCEEEEE 3.61%HC032212679in vitro
34620QNPLPVALEG C TFTVEGAGLT EECCCCEECC E EEEEECCCCC 1.75%HC1222178444-
35620QNPLPVALEG C TFTVEGAGLT EECCCCEECC E EEEEECCCCC 1.75%HC1211305905in vitro