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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Talin-1

UniprotKB/SwissProt ID: TLN1_HUMAN (Q9Y490)

Gene Name: TLN1

Synonyms: KIAA1027, TLN

Organism: Homo sapiens (Human).

Function: Probably involved in connections of major cytoskeletal structures to the plasma membrane. High molecular weight cytoskeletal protein concentrated at regions of cell-substratum contact and, in lymphocytes, at cell-cell contacts (By similarity).

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cell projection, ruffle membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Cytoplasm, cytoskeleton (By similarity). Cell surface (By similarity). Cell junction, focal adhesion (By similarity). Note=Colocalizes with LAYN at the membr

PDB :
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Protein disease:
Disease database Database Entry Disease information
OMIM186745TALIN 1; TLN1 ;;TALIN; TLN
Network with metabolic pathway:
Kegg map ID Pathway Link
map04510Focal adhesion
map05166HTLV-I infection
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR000299
IPR002558
IPR011993
IPR014352
IPR015009
IPR015224
IPR015710

The S-nitrosylation sites of TLN1_HUMAN

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
129FEPSTMVYDA C RIIRERIPEA CCHHHHHHHH H HHHHHCCCCC 2.68%HC122212679in vitro
2251FNNERAANAL C AGMRVTGCNT HHHHHHHCCC C HHHCCCCCCC 57.43%HC1225040305in vivo
3286ERKIFQAHKN C GQMSEIEAKV HHHHHHHHHH H HCCCHHHHHH 4.83%HC092212679in vitro
41939ALVTKAGALQ C SPSDAYTKKE HHHHCCCCCE E CCCCCHHHHH 7.22%HC0822178444-