logo
  Home | Contact us | Browse | Quick Search by UniProtKB ID, Keyword, PDBID

Menu:

Latest news:

Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

Read more...


Protein Name: Serotransferrin

UniprotKB/SwissProt ID: TRFE_HUMAN (P02787)

Gene Name: TF

Organism: Homo sapiens (Human).

Function: Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Secreted.

PDB :
( If your security settings prevent Jmol from running, please register http://140.138.144.145/ as a safe location in your Java settings. )

Protein disease:
Disease database Database Entry Disease information
HPRD01811Atransferrinemia
HPRD01811Iron deficiency anemia, susceptibility to
HPRD01811Transferrin variant B2
HPRD01811Transferrin variant BV
HPRD01811Transferrin variant C1/C2
HPRD01811Transferrin variant CHI
HPRD01811Transferrin variant D1
Network with metabolic pathway:
Kegg map ID Pathway Link
map04978Mineral absorption
map04066HIF-1 signaling pathway
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR001156

The S-nitrosylation sites of TRFE_HUMAN

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
158VIPSDGPSVA C VKKASYLDCI CCCCCCCEEE E ECCCCHHHHH 4.29%HC0525040305in vivo
2137QMNQLRGKKS C HTGLGRSAGW CHHHHCCCEE E CCCCCCCCCC 4.59%HC0325040305in vivo
3213QYFGYSGAFK C LKDGAGDVAF CCCCHHHHHH H HHCCCCCEEE 4.63%HC0225040305in vivo
4246KADRDQYELL C LDNTRKPVDE CCCCCCCEEE C CCCCCCCCCC 7.58%HC0125040305in vivo
5260TRKPVDEYKD C HLAQVPSHTV CCCCCCCCCC C CCCCCCEEEE 2.18%HC0325040305in vivo
6364PTDECKPVKW C ALSHHERLKC CCCCCCCEEE E ECCHHHHHHH 1.95%HC0925040305in vivo
7374CALSHHERLK C DEWSVNSVGK EECCHHHHHH H HHHHHHCCCC 7.30%HC0225040305in vivo
8396ECVSAETTED C IAKIMNGEAD EEEECCCHHH H HHHHHCCCCC 2.37%HC0625040305in vivo
9503CRFDEFFSEG C APGSKKDSSL CCCHHHCCCC C CCCCCCCCCC 3.47%HC0725040305in vivo
10525KLCMGSGLNL C EPNNKEGYYG CCCCCCCCCC C CCCCCCCCCC 8.76%HC1225040305in vivo
11582NLNEKDYELL C LDGTRKPVEE CCCCCCCEEE C CCCCCCCHHH 5.21%HC1225040305in vivo
12596TRKPVEEYAN C HLARAPNHAV CCCCHHHHHH C CCCCCCCCEE 1.80%HC0725040305in vivo
13684YVKAVGNLRK C STSSLLEACT HHHHHHHHHC C CCHHHHHHHH 4.30%HC0225040305in vivo