Protein Name: Tripartite motif-containing protein 72
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UniprotKB/SwissProt ID: TRI72_RAT (A0JPQ4)
Gene Name: Trim72
Synonyms: Mg53
Organism: Rattus norvegicus (Rat).
Function: Muscle-specific protein that plays a central role in cell membrane repair by nucleating the assembly of the repair machinery at injury sites. Specifically binds phosphatidylserine. Acts as a sensor of oxidation: upon membrane damage, entry of extracellular oxidative environment results in disulfide bond formation and homooligomerization at the injury site. This oligomerization acts as a nucleation site for recruitment of TRIM72-containing vesicles to the injury site, leading to membrane patch formation. Probably acts upstream of the Ca(2+)-dependent membrane resealing process. Required for transport of DYSF to sites of cell injury during repair patch formation. Regulates membrane budding and exocytosis. May be involved in the regulation of the mobility of KCNB1-containing endocytic vesicles (By similarity).
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell membrane, sarcolemma (By similarity). Cytoplasmic vesicle membrane (By similarity). Note=Tethered to plasma membrane and cytoplasmic vesicles via its interaction with phosphatidylserine (By similarity).
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Graphical Visualization of S-nitrosylation Sites:
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| Overview of Protein S-nitrosylation Sites with Functional and Structural Information |  |
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