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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Transthyretin

UniprotKB/SwissProt ID: TTHY_HUMAN (P02766)

Gene Name: TTR

Synonyms: PALB

Organism: Homo sapiens (Human).

Function: Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Secreted. Cytoplasm.

PDB :
( If your security settings prevent Jmol from running, please register http://140.138.144.145/ as a safe location in your Java settings. )

Protein disease:
Disease database Database Entry Disease information
HPRD01447Amyloid cardiomyopathy
HPRD01447Amyloid polyneuropathy
HPRD01447Amyloid polyneuropathy, Andrade or Portuguese type
HPRD01447Amyloid polyneuropathy, Appalachian type
HPRD01447Amyloid polyneuropathy, German-American type
HPRD01447Amyloid polyneuropathy, Jewish type
HPRD01447Amyloid polyneuropathy, Mahloudji or Maryland type
HPRD01447Amyloid polyneuropathy, Polish-American
HPRD01447Amyloid polyneuropathy, Rukavina or Indiana type
HPRD01447Amyloidosis, cardiac or Denmark type
HPRD01447Amyloidosis, familial
HPRD01447Amyloidosis, leptomeningeal
HPRD01447Amyloidosis, oculoleptomeningeal
HPRD01447Amyloidosis, Senile
HPRD01447Amyloidosis, systemic, neuropathic, and leptomeningeal
HPRD01447Carpal tunnel syndrome, familial
HPRD01447Hyperthyroxinemia, familial dysprealbuminemic euthyroid
HPRD01447Prealbumin Chicago
HPRD01447Transthyretin acidic Asn-90 variant
HPRD01447Transthyretin polymorphism
HPRD01447Transthyretin Ser-6 polymorphism
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR000895
3D Structure Databases:
3D structure databases
EntryMethodResolution (A)ChainPositionsView
1BM7 X-ray 2.00 A A/B21-147Link
1BMZ X-ray 2.00 A A/B21-147Link
1BZ8 X-ray 2.00 A A/B21-141Link
1BZD X-ray 1.90 A A/B21-147Link
1BZE X-ray 1.80 A A/B21-147Link
1DVQ X-ray 2.00 A A/B21-144Link
1DVS X-ray 2.00 A A/B21-144Link
1DVT X-ray 1.90 A A/B21-144Link
1DVU X-ray 1.90 A A/B21-144Link
1DVX X-ray 2.00 A A/B21-144Link
1DVY X-ray 1.90 A A/B21-144Link
1DVZ X-ray 1.90 A A/B21-144Link
1E3F X-ray 1.90 A A/B21-145Link
1E4H X-ray 1.80 A A/B21-147Link
1E5A X-ray 1.80 A A/B21-147Link
1ETA X-ray 1.70 A 1/221-147Link
1ETB X-ray 1.70 A 1/221-147Link
1F41 X-ray 1.30 A A/B21-147Link
1F64 Model - A21-147Link
1F86 X-ray 1.10 A A/B30-144Link
1FH2 X-ray 1.80 A A/B21-147Link
1FHN X-ray 1.75 A A/B21-147Link
1G1O X-ray 2.30 A A/B/C/D21-147Link
1GKO X-ray 2.10 A A/B/C/D21-147Link
1ICT X-ray 3.00 A A/B/C/D/E/F/G/H21-147Link
1III X-ray 2.00 A A/B21-147Link
1IIK X-ray 2.00 A A/B21-147Link
1IJN X-ray 1.70 A A/B21-147Link
1QAB X-ray 3.20 A A/B/C/D21-147Link
1QWH X-ray 1.36 A A/B31-147Link
1RLB X-ray 3.10 A A/B/C/D21-147Link
1SOK X-ray 1.60 A A/B21-147Link
1SOQ X-ray 2.10 A A/B/C/D21-147Link
1THA X-ray 2.00 A A/B21-147Link
1THC X-ray 2.30 A A/B21-147Link
1TLM X-ray 1.90 A A/B21-147Link
1TSH X-ray 1.70 A A/B21-147Link
1TT6 X-ray 1.80 A A/B21-147Link
1TTA X-ray 1.70 A A/B21-147Link
1TTB X-ray 1.70 A A/B21-147Link
1TTC X-ray 1.70 A A/B21-147Link
1TTR X-ray 1.90 A A/B21-147Link
1TYR X-ray 1.80 A A/B21-147Link
1TZ8 X-ray 1.85 A A/B/C/D21-147Link
1U21 X-ray 1.69 A A/B21-147Link
1X7S X-ray 1.55 A A/B21-147Link
1X7T X-ray 1.60 A A/B21-147Link
1Y1D X-ray 1.70 A A/B21-147Link
1Z7J X-ray 2.20 A A/B21-147Link
1ZCR X-ray 1.80 A A/B21-147Link
1ZD6 X-ray 1.90 A A/B21-147Link
2B14 X-ray 2.00 A A/B21-147Link
2B15 X-ray 1.70 A A/B21-147Link
2B16 X-ray 1.75 A A/B21-147Link
2B77 X-ray 1.70 A A/B21-147Link
2B9A X-ray 1.54 A A/B21-147Link
2F7I X-ray 1.60 A A/B21-147Link
2F8I X-ray 1.54 A A/B21-147Link
2FBR X-ray 1.46 A A/B21-147Link
2FLM X-ray 1.65 A A/B21-147Link
2G3X X-ray 1.58 A A/B21-147Link
2G3Z X-ray 1.90 A A/B21-147Link
2G4E X-ray 2.17 A A/B21-147Link
2G4G X-ray 1.85 A A/B21-147Link
2G5U X-ray 1.80 A A/B21-147Link
2G9K X-ray 1.85 A A/B21-147Link
2GAB X-ray 1.85 A A/B21-147Link
2H4E X-ray 1.45 A A/B21-147Link
2M5N NMR - A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P125-135Link
2NOY X-ray 1.80 A A/B21-147Link
2PAB X-ray 1.80 A A/B21-147Link
2QEL X-ray 2.29 A A/B/C/D21-147Link
2QGB X-ray 1.40 A A/B21-147Link
2QGC X-ray 1.30 A A/B21-147Link
2QGD X-ray 1.50 A A/B21-147Link
2QGE X-ray 1.45 A A/B21-147Link
2ROX X-ray 2.00 A A/B21-147Link
2ROY X-ray 2.20 A A/B21-147Link
2TRH X-ray 1.90 A A/B21-147Link
2TRY X-ray 2.00 A A/B21-147Link
2WQA X-ray 2.85 A A/B/C/D21-147Link
3A4D X-ray 2.00 A A/B21-147Link
3A4E X-ray 1.70 A A/B21-147Link
3A4F X-ray 1.99 A A/B21-147Link
3B56 X-ray 1.55 A A/B21-147Link
3BSZ X-ray 3.38 A A/B/C/D21-147Link
3BT0 X-ray 1.59 A A/B21-147Link
3CBR X-ray 1.70 A A/B21-147Link
3CFM X-ray 1.60 A A/B30-147Link
3CFN X-ray 1.87 A A/B30-147Link
3CFQ X-ray 2.09 A A/B30-147Link
3CFT X-ray 1.87 A A/B30-147Link
3CN0 X-ray 1.52 A A/B21-147Link
3CN1 X-ray 1.52 A A/B21-147Link
3CN2 X-ray 1.52 A A/B21-147Link
3CN3 X-ray 1.80 A A/B21-147Link
3CN4 X-ray 1.40 A A/B21-147Link
3CXF X-ray 2.30 A A/B21-147Link
3D2T X-ray 1.85 A A/B21-147Link
3D7P X-ray 1.72 A A/B21-147Link
3DGD X-ray 1.38 A A/B/C/D21-147Link
3DID X-ray 1.78 A A/B/C/D21-147Link
3DJR X-ray 2.02 A A/B21-147Link
3DJS X-ray 1.80 A A/B21-147Link
3DJT X-ray 2.30 A A/B21-147Link
3DJZ X-ray 1.82 A A/B21-147Link
3DK0 X-ray 1.87 A A/B21-147Link
3DK2 X-ray 2.35 A A/B21-147Link
3DO4 X-ray 2.40 A A/B/C/D/E/F/G/H21-147Link
3ESN X-ray 1.35 A A/B21-147Link
3ESO X-ray 1.31 A A/B21-147Link
3ESP X-ray 1.31 A A/B21-147Link
3FC8 X-ray 1.85 A A/B21-144Link
3FCB X-ray 1.80 A A/B21-144Link
3GLZ X-ray 1.78 A A/B21-147Link
3GPS X-ray 1.78 A A/B/C/D21-147Link
3GRB X-ray 1.75 A A/B/C/D21-147Link
3GRG X-ray 1.90 A A/B/C/D21-147Link
3GS0 X-ray 1.85 A A/B21-147Link
3GS4 X-ray 1.78 A A/B21-147Link
3GS7 X-ray 1.80 A A/B21-147Link
3HJ0 X-ray 1.34 A A/B21-147Link
3I9A X-ray 1.65 A A/B21-147Link
3I9I X-ray 1.80 A A/B30-145Link
3I9P X-ray 1.90 A A/B30-145Link
3IMR X-ray 1.70 A A/B21-147Link
3IMS X-ray 1.40 A A/B21-147Link
3IMT X-ray 1.40 A A/B21-147Link
3IMU X-ray 1.40 A A/B21-147Link
3IMV X-ray 1.47 A A/B21-147Link
3IMW X-ray 1.31 A A/B21-147Link
3IPB X-ray 1.90 A A/B21-147Link
3IPE X-ray 1.40 A A/B21-147Link
3KGS X-ray 1.80 A A/B21-147Link
3KGT X-ray 1.95 A A/B21-147Link
3KGU X-ray 1.85 A A/B21-147Link
3M1O X-ray 1.20 A A/B21-147Link
3NEE X-ray 1.55 A A/B30-145Link
3NEO X-ray 2.00 A A/B30-145Link
3NES X-ray 1.75 A A/B30-145Link
3NEX X-ray 1.70 A A/B30-145Link
3NG5 X-ray 1.70 A A/B21-147Link
3OZK X-ray 1.90 A A/B21-147Link
3OZL X-ray 1.90 A A/B21-147Link
3P3R X-ray 1.25 A A/B21-147Link
3P3S X-ray 1.60 A A/B21-147Link
3P3T X-ray 1.45 A A/B21-147Link
3P3U X-ray 1.50 A A/B21-147Link
3SSG X-ray 2.00 A A21-147Link
3TCT X-ray 1.30 A A/B21-147Link
3TFB X-ray 2.03 A A/B30-145Link
3U2I X-ray 1.70 A A/B32-147Link
3U2J Neutron 2.00 A A/B32-147Link
3W3B X-ray 1.90 A A/B21-147Link
4ABQ X-ray 1.70 A A/B21-144Link
4ABU X-ray 1.86 A A/B21-144Link
4ABV X-ray 1.80 A A/B21-144Link
4ABW X-ray 1.70 A A/B21-144Link
4AC2 X-ray 1.81 A A/B21-144Link
4AC4 X-ray 1.80 A A/B21-147Link
4ACT X-ray 1.80 A A/B21-147Link
4ANK X-ray 1.70 A A/B1-147Link
4DER X-ray 1.90 A A/B30-145Link
4DES X-ray 1.75 A A/B30-145Link
4DET X-ray 2.05 A A/B30-145Link
4DEU X-ray 1.60 A A/B30-145Link
4DEW X-ray 1.90 A A/B1-147Link
4FI6 X-ray 1.46 A A/B21-147Link
4FI7 X-ray 1.40 A A/B21-147Link
4FI8 X-ray 1.22 A A/B21-147Link
4HIQ X-ray 1.18 A A/B21-147Link
4HIS X-ray 1.20 A A/B21-147Link
4HJS X-ray 1.22 A A/B30-145Link
4HJT X-ray 1.45 A A/B21-147Link
4HJU X-ray 1.35 A A/B21-147Link
4I85 X-ray 1.67 A A/B21-147Link
4I87 X-ray 1.69 A A/B21-147Link
4I89 X-ray 1.69 A A/B21-147Link
4IIZ X-ray 2.10 A A/B21-147Link
4IK6 X-ray 2.00 A A/B21-147Link
4IK7 X-ray 2.10 A A/B21-147Link
4IKI X-ray 2.00 A A/B21-147Link
4IKJ X-ray 2.10 A A/B21-147Link
4IKK X-ray 1.90 A A/B21-147Link
4IKL X-ray 1.90 A A/B21-147Link
4KY2 X-ray 1.13 A A/B21-147Link
4L1S X-ray 1.50 A A/B21-147Link
4L1T X-ray 1.16 A A/B21-147Link
4MAS X-ray 1.22 A A/B21-147Link
4MRB X-ray 1.27 A A/B21-147Link
4MRC X-ray 1.54 A A/B22-147Link
4N85 X-ray 1.60 A A/B1-147Link
4N86 X-ray 2.00 A A/B1-147Link
4N87 X-ray 1.79 A A/B1-147Link
5TTR X-ray 2.70 A A/B/C/D/E/F/G/H21-147Link
The S-nitrosylation sites of TTHY_HUMAN

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
110-MASHRLLLL C LAGLVFVSEA -CCHHHHHHH H HHHHHHHHCC 2.17%HC1222178444-
210-MASHRLLLL C LAGLVFVSEA -CCHHHHHHH H HHHHHHHHCC 2.17%HC1216101296-