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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Ubiquitin-like modifier-activating enzyme 1

UniprotKB/SwissProt ID: UBA1_HUMAN (P22314)

Gene Name: UBA1

Synonyms: A1S9T, UBE1

Organism: Homo sapiens (Human).

Function: Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin- E1 thioester and free AMP.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization:

Network with metabolic pathway:
Kegg map ID Pathway Link
map05012Parkinson's disease
map04120Ubiquitin mediated proteolysis
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information

The S-nitrosylation sites of UBA1_HUMAN

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
1234VTKDNPGVVT C LDEARHGFES   2.81%HC0722178444-
2234VTKDNPGVVT C LDEARHGFES   2.81%HC0720140087in vivo
3632QDPPEKSIPI C TLKNFPNAIE   2.82%HC0619483679in vivo