Protein Name: E3 ubiquitin-protein ligase UBR4
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UniprotKB/SwissProt ID: UBR4_MOUSE (A2AN08)
Gene Name: Ubr4
Synonyms: Kiaa0462, Zubr1
Organism: Mus musculus (Mouse).
Function: E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Together with clathrin, forms meshwork structures involved in membrane morphogenesis and cytoskeletal organization. Regulates integrin-mediated signaling. May play a role in activation of FAK in response to cell-matrix interactions. Mediates ubiquitination of ACLY, leading to its subsequent degradation.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Membrane; Multi-pass membrane protein (Potential). Cytoplasm (By similarity). Cytoplasm, cytoskeleton (By similarity). Nucleus (By similarity). Note=Concentrates at the leading edge of membrane structures involved in actin motility (By similarity).
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Network with metabolic pathway:
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Graphical Visualization of S-nitrosylation Sites:
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| Overview of Protein S-nitrosylation Sites with Functional and Structural Information |  |
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